DSIP

A neuropeptide that modulates sleep architecture and circadian rhythms. One of the most studied sleep-related peptides in preclinical research.

Modulates delta wave sleep architecture, interacts with the hypothalamic pituitary axis, reduces cortisol and stress hormone activity, and has antioxidant properties.

DSIP does not sedate you like a sleeping pill. It works with your body's natural sleep architecture to improve quality and depth of sleep rather than forcing unconsciousness.

• Delta wave EEG activity
• Sleep onset latency
• Cortisol rhythm
• Circadian phase markers
• Stress response indices

• Sleep quality and architecture
• Circadian rhythm regulation
• Stress resilience
• Cortisol modulation
• Neuroprotection

First isolated in the 1970s by Schoenenberger and Monnier from the cerebral venous blood of rabbits in induced slow-wave sleep.

Men and women 30-65 with poor sleep quality, circadian disruption, chronic stress, shift work or jet lag.

• Reconstitute with bacteriostatic or sterile water.
• Add diluent slowly down the vial wall.
• Very short half-life, evening timing is standard in protocols.
• Store lyophilised at -20C, reconstituted at 4C.
• Protect from light.

• Not a sedative, works on architecture rather than sedation.
• Short half-life, timing relative to sleep onset matters.
• Human evidence base is limited compared with preclinical data.
• Often paired with Selank or Epithalon in sleep protocols.