Melanotan II

A non-selective melanocortin agonist that stimulates melanogenesis for skin darkening. It also has libido and appetite suppression effects, discovered as secondary findings.

Non-selectively activates melanocortin receptors including MC1R for melanogenesis and MC3R/MC4R for libido and appetite effects.

Originally developed as a sunless tanning compound. Researchers discovered significant libido and appetite effects as secondary findings.

• Melanin density and skin pigmentation
• Appetite and food intake
• Erectile response
• Receptor selectivity profiling

• Melanogenesis and skin pigmentation
• Erectile function
• Libido enhancement
• Appetite suppression

Developed at the University of Arizona during research into melanocortin analogues intended to reduce UV exposure through induced pigmentation.

Men and women 25-50 researching tanning, libido support and appetite suppression.

• Reconstitute with bacteriostatic water.
• Add diluent slowly down the vial wall and swirl.
• Store lyophilised at -20C away from light.
• Reconstituted solution stable up to 30 days at 4C.
• Avoid freeze-thaw cycles.

• Non-selective receptor binding produces broad effects.
• Nausea and flushing commonly reported in literature.
• Pigmentation changes including existing nevi are documented.
• Distinct from the selective PT-141 profile.