Botulinum Toxin

A neurotoxic protein that temporarily paralyses targeted facial muscles to reduce dynamic wrinkles. The most widely used cosmetic research compound globally.

Cleaves SNAP-25 to block acetylcholine release at the neuromuscular junction, temporarily preventing targeted muscle contraction.

Dynamic wrinkles come from repeated muscle movement. Botulinum toxin temporarily interrupts the signal telling those specific muscles to contract, so the overlying skin stops creasing while the effect lasts.

• Wrinkle severity scoring
• Muscle contraction amplitude
• Duration of effect
• Sweat production in hyperhidrosis models
• Migraine frequency

• Facial line reduction
• Hyperhidrosis
• Migraine prevention
• Muscle spasticity

Isolated from Clostridium botulinum and first used therapeutically for strabismus in the 1970s, with cosmetic applications following after incidental observation of wrinkle softening.

Women and men 30 plus focused on facial line reduction, cosmetic research, and forehead and eye area wrinkles.

• Reconstitute with preservative-free sterile saline.
• Add diluent extremely slowly, never agitate.
• Highly sensitive to agitation and heat.
• Store refrigerated at 2-8C and use promptly.
• Handle only in appropriate laboratory conditions.

• Potency is unit-based, not weight-based.
• Effects are localised and temporary, typically 3-4 months.
• Extremely handling sensitive compared with peptides.
• Strictly controlled in most research jurisdictions.